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Ectopic expression also partly compensates for the effects of knockdown.

We demonstrate that Ronin binds directly to HCF-1, a key transcriptional regulator.

Pluripotency is a unique biological state that allows cells to differentiate into any tissue type.

Here we describe a candidate pluripotency factor, Ronin, that possesses a THAP domain, which is associated with sequence-specific DNA binding and epigenetic silencing of gene expression.

Managed by the Office of Professional Education at National Jewish Health in partnership with Medscape, the activity features a 30-minute video discussion between experts in the diagnosis and management of Rheumatoid Arthritis (RA) and its comorbidities.

National Jewish Health faculty Barbara Goldstein, MD, MMSc, Assistant Professor, Division of Rheumatology, moderates the discussion with colleague Darlene Kim, MD, FACC, Assistant Professor, Division of Cardiology, and Denver Health’s Jennifer Stichman, MD, Divisions of Internal Medicine and Rheumatology.

This activity was supported by an educational grant from Pfizer, Inc.

“This course did a nice job of stressing that cardiovascular risk is not a theoretical risk for RA patients, but a real thing that you have to consider,” said Emilie Fagin, NP, National Jewish Health, Division of Rheumatology, who added that she gleaned useful tools from the course to talk with her patients about this risk.Ronin is expressed primarily during the earliest stages of murine embryonic development, and its deficiency in mice produces periimplantational lethality and defects in the inner cell mass.Conditional knockout of Ronin prevents the growth of ES cells while forced expression of Ronin allows ES cells to proliferate without differentiation under conditions that normally do not promote self-renewal. The film stars Keanu Reeves, and tells the story of a band of samurai, who set out to get revenge for the death of their master.The movie has been directed by Carl Rinsch, and Universal Pictures has been footing a hefty nine figure bill to get it this far.

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